We Compared 5 Ways to Raise NAD+. Here's Why We Built a 10-in-1.
We Compared 5 Ways to Raise NAD+. Here's Why We Built a 10-in-1.
Most options only fill your NAD+. AUVRA also works on the drain.
From the AUVRA team · Updated October 2026 · 5 min read
You already know about NAD+.
It's a helper molecule. Your cells need it to make energy. When scientists measured it in people, older adults tended to have less.
So you've looked at ways to raise it. Capsules. Powders. Drips at a clinic.
Here's the question most labels skip:
What happens to NAD+ after you make it?
Your body also breaks NAD+ down. An enzyme called CD38 is a big part of that. In aging mice, CD38 rose 2–3x in every tissue tested.
So raising NAD+ is like filling a tub with the plug out.
Most products only work on the fill. That's why we compared the main options on both jobs.
What our #1 pick has
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Fill: NMNNMN is what your body turns into NAD+. The full formula is 1,000 mg per serving.
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Seal: apigenin + quercetinBoth were studied against CD38, the NAD+ drain.
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10 ingredients, one bottlePlus resveratrol and CoQ10 for the energy chain inside your cells.
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Every day, no stimulant2 vegetarian capsules a day. Zero caffeine.
So how do you choose?
There are a lot of NAD+ products now. They don't all do the same job.
Some fill. Some need a needle. Some are one ingredient and nothing else.
Price tells you little. A label tells you more, if you know what to read.
So we picked 5 plain questions and ran every kind of product through them.
How we compared them
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1Fill: does it raise NAD+?Is there a precursor, or NAD+ itself, with human research behind it?
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2Seal: anything for the drain?Is there an ingredient aimed at CD38?
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3One ingredient or a full formula?Single ingredient, or a stack with support for the energy chain?
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4Easy to keep up?A daily capsule at home, or a clinic visit?
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5Clear label and fair price?Can you see the amount per serving? Is there a guarantee?
Honest note: AUVRA is our product. These verdicts are our own, based on what each kind of product contains and how it's taken. They are not lab scores, and we didn't test other companies' products.
#1 Our pick: AUVRA NMN, Ultimate 10-in-1
OUR #1 PICK (we make it)
AUVRA is built to do both jobs, not just the fill.
Fill. NMN is what your body turns into NAD+.
In a 60-day placebo-controlled trial, 80 healthy middle-aged adults took 300, 600 or 900 mg of NMN once a day. Their blood NAD+ levels were higher at day 30 and day 60 than with placebo.
(That study tested NMN on its own, not AUVRA. Yi L, Maier AB, et al. GeroScience 2023;45(1):29–43. PMID 36482258.)
Seal. Apigenin and quercetin were studied against CD38, an enzyme that breaks NAD+ down.
Spark. Resveratrol and CoQ10 are part of the energy chain inside your cells.
That's 10 ingredients: NMN, vitamin C, resveratrol, grape seed, CoQ10, glutathione, TMG, quercetin, astaxanthin and apigenin.
1,000 mg per serving. 60 vegetarian capsules, 2 per serving, 30 servings.
| Question | AUVRA |
|---|---|
| Fill | NMN |
| Seal | Apigenin + quercetin, studied against CD38 |
| One or full formula | 10-in-1 |
| Easy to keep up | 2 capsules a day, at home |
| Label and price | 1,000 mg per serving printed; from $19.95; 30-day guarantee |
Right now: up to 70% off. One bottle is $19.95 (compare-at $49.99).
#2: Plain single-ingredient NMN
The most common choice, and a fair start.
NMN is a real NAD+ precursor with human research.
But a plain NMN bottle is one ingredient. There's nothing in it aimed at CD38, so it's all fill and no seal.
The cheapest ones from big marketplaces add another problem: the listing often shows no lab report, so you're trusting the label.
| Question | Plain NMN |
|---|---|
| Fill | NMN |
| Seal | No CD38 support |
| One or full formula | Single ingredient |
| Easy to keep up | Daily capsule |
| Label and price | Varies; check the dose per serving |
#3: NR (nicotinamide riboside)
NR is another NAD+ precursor, with human studies of its own.
It's a solid idea. But a typical NR product is NR alone: one ingredient, with nothing for CD38.
Same story as plain NMN. Fill, no seal.
| Question | NR |
|---|---|
| Fill | NR |
| Seal | No CD38 support |
| One or full formula | Usually single ingredient |
| Easy to keep up | Daily capsule |
#4: Liposomal or sublingual NAD+
These sell NAD+ itself, not a precursor, wrapped in fat bubbles or held under the tongue.
The pitch is better uptake. But there's less human research on swallowed or under-the-tongue NAD+ than on NMN.
And like most options here, there's usually nothing for CD38.
| Question | Liposomal / sublingual NAD+ |
|---|---|
| Fill | Less human research than NMN |
| Seal | Usually no CD38 support |
| Easy to keep up | Daily, at home |
#5: NAD+ IV drips
The most direct route. NAD+ goes straight into a vein.
But it needs a clinic visit and a needle, and you pay per session.
When you leave, there's nothing working on the CD38 drain. And you can't do it every morning at your kitchen table.
| Question | IV drip |
|---|---|
| Fill | NAD+ into the vein |
| Seal | No CD38 support |
| Easy to keep up | Needs a clinic visit |
| Label and price | Priced per session |
Why NAD+ matters for steady energy
NAD+ helps your cells get energy out of food.
Think of it as water in a tub. NMN fills the tub.
CD38 is the drain. In aging mice, it rose 2–3x in every tissue tested.
If you only fill, some of that NAD+ goes down the drain.
Fill & Seal does both: NMN to fill, apigenin and quercetin to help seal.
Look for this, skip that
Look for
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The dose per serving, printedAUVRA: 1,000 mg per serving.
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Something for CD38Apigenin and quercetin are the two to look for.
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Energy-chain supportCoQ10 and resveratrol work alongside NAD+ in your cells.
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A real guaranteeOurs: 30-day guarantee, your money back if it's not for you.
Skip
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Hidden amounts"Blend" with no numbers per ingredient? You can't judge it.
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Fill-only formulasOne precursor and nothing for the drain.
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Stimulant "energy" pillsMany get their kick from caffeine, guarana or green tea extract. That's a push, not NAD+.
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A clinic habit you can't keepIf it needs a needle and an appointment, it won't be a daily habit.
What AUVRA customers told us*
- 91%reported better energy or clarity within 3 weeks*
- 92%said mornings felt easier*
- 89%reported no stomach issues*
- 87%said they would keep using it*
*Based on internal studies and customer feedback surveys.
Reviews
"Finally supporting things at the cellular level."
I've tried supplements that promise a lot but don't explain how they work. This felt different. Supporting NAD+ made more sense to me long term.
"A clean product I actually trust."
I like that the formula is simple and focused. No unnecessary ingredients, just what's needed. It fits easily into my routine and gives me peace of mind.
Is a daily supplement the right way to support NAD+?
For most people, a daily capsule is the simplest habit to keep.
The research on NMN is in humans, and it's encouraging. The Yi 2023 trial saw higher blood NAD+ at day 30 and day 60.
But what you take matters. One ingredient fills. A 10-in-1 with a CD38 seal covers both jobs: fill and seal.
Our verdict
Four of these options stop at the fill, or need a clinic.
AUVRA NMN, Ultimate 10-in-1, was the one option we compared with fill and seal, 10 ingredients, and a daily 2-capsule routine.
Yes, we're biased: we make it. That's why our 30-day guarantee means your money back if it's not for you.
AUVRA NMN, Ultimate 10-in-1. Up to 70% off.
- 1 bottle: $19.95 (compare-at $49.99)
- Buy 2, Get 1 Free: 3 bottles for $39.95. Most Popular
- Buy 3, Get 2 Free: 5 bottles for $59.95. $11.99 each, with free shipping
- 1,000 mg per serving · 60 vegetarian capsules · 30 servings
- Fill & Seal: NMN + apigenin and quercetin
- 30-day guarantee: your money back if it's not for you
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Check with your doctor before you start any supplement if you are pregnant, nursing, take medication, or have a medical condition. This page is an advertisement written by AUVRA.